Estimating the Time to Diagnosis and the Chance of Spontaneous Clearance During Acute Hepatitis C in Human Immunodeficiency Virus-Infected Individuals
Identifieur interne : 000C97 ( Main/Exploration ); précédent : 000C96; suivant : 000C98Estimating the Time to Diagnosis and the Chance of Spontaneous Clearance During Acute Hepatitis C in Human Immunodeficiency Virus-Infected Individuals
Auteurs : Romain Ragonnet [France, Australie] ; Sylvie Deuffic-Burban [France] ; Christoph Boesecke [Allemagne] ; Marguerite Guiguet [France] ; Karine Lacombe [France] ; Jeremie Guedj [France] ; Jürgen K. Rockstroh [Allemagne] ; Yazdan Yazdanpanah [France]Source :
- Open Forum Infectious Diseases [ 2328-8957 ] ; 2017.
Abstract
Hepatitis C virus (HCV) infection is often asymptomatic, and the date of infection is almost impossible to determine. Furthermore, spontaneous clearance (SC) may occur, but little is known about its time of occurrence.
Data on human immunodeficiency virus (HIV)-HCV coinfected individuals were used to inform a stochastic simulation model of HCV viral load kinetics, alanine aminotransferase (ALT), and HCV antibodies during acute hepatitis C. The dates of diagnosis and potential SC were estimated through a Bayesian approach. Hepatitis C virus diagnosis was assumed to be based on an elevated ALT level detected during a control visit for HIV-infected individuals, which occurred every 3 months (scenario A) or every 6 months (scenario B).
We found that HCV diagnosis occurred after a median of 115 days and 170 days of infection in scenarios A and B, respectively. Among spontaneous clearers, SC occurred after a median time of 184 days after infection. Seven percent (scenario B) to 10% (scenario A) of SCs appeared more than 6 months after diagnosis, and 3% (both scenarios) of SCs appeared more than 1 year after diagnosis.
Acute hepatitis C diagnosis occurs late in HIV-HCV coinfected individuals. Screening for HCV in HIV-infected individuals should be performed frequently to reduce delays. Our findings about late occurrence of SC support “wait and see” strategies for treatment initiation from an individual basis. However, early treatment initiation may reduce HCV transmission.
Url:
DOI: 10.1093/ofid/ofw235
PubMed: 28480234
PubMed Central: 5414115
Affiliations:
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Université Paris Diderot, Sorbonne Paris Cité</institution>,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Beckman Research Institute, City of Hope, 1500 E Duarte Road, Duarte</wicri:regionArea><wicri:noRegion>Duarte</wicri:noRegion><wicri:noRegion>Duarte</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>University of Melbourne, Department of Medicine, Dentistry and Health Sciences</institution>,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deuffic Burban, Sylvie" sort="Deuffic Burban, Sylvie" uniqKey="Deuffic Burban S" first="Sylvie" last="Deuffic-Burban">Sylvie Deuffic-Burban</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Institut National de la Santé et de la Recherche Médicale (INSERM), Infection, Antimicrobiens, Modélisation, Evolution, Unité Mixte de Recherche (UMR) 1137</institution>,<country>Paris, France</country><institution>; Université Paris Diderot, Sorbonne Paris Cité</institution>,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Beckman Research Institute, City of Hope, 1500 E Duarte Road, Duarte</wicri:regionArea><wicri:noRegion>Duarte</wicri:noRegion><wicri:noRegion>Duarte</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Université de Lille, INSERM, Centre Hospitalier Universitaire Lille, U995 - Lille Inflammation Research International Center</institution>,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boesecke, Christoph" sort="Boesecke, Christoph" uniqKey="Boesecke C" first="Christoph" last="Boesecke">Christoph Boesecke</name><affiliation wicri:level="1"><nlm:aff id="AF0004"><institution>Department of Internal Medicine 1, Rheinische Friedrich-Wilhelms University Bonn</institution>,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0005"><institution>German Centre of Infection Research (DZIF)</institution>,<addr-line>partner site Cologne-Bonn</addr-line>,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guiguet, Marguerite" sort="Guiguet, Marguerite" uniqKey="Guiguet M" first="Marguerite" last="Guiguet">Marguerite Guiguet</name><affiliation wicri:level="1"><nlm:aff id="AF0006"><institution>Sorbonne Universités, Université Pierre et Marie Curie, Université Paris 06, INSERM, Institut Pierre Louis d’Épidémiologie et de Santé Publique (UMRS 1136)</institution>,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lacombe, Karine" sort="Lacombe, Karine" uniqKey="Lacombe K" first="Karine" last="Lacombe">Karine Lacombe</name><affiliation wicri:level="1"><nlm:aff id="AF0006"><institution>Sorbonne Universités, Université Pierre et Marie Curie, Université Paris 06, INSERM, Institut Pierre Louis d’Épidémiologie et de Santé Publique (UMRS 1136)</institution>,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0007"><institution>Service de Maladies Infectieuses et Tropicales, Hôpital Saint-Antoine</institution>,<country>Paris, France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Beckman Research Institute, City of Hope, 1500 E Duarte Road, Duarte</wicri:regionArea><wicri:noRegion>Duarte</wicri:noRegion><wicri:noRegion>Duarte</wicri:noRegion></affiliation></author><author><name sortKey="Guedj, Jeremie" sort="Guedj, Jeremie" uniqKey="Guedj J" first="Jeremie" last="Guedj">Jeremie Guedj</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Institut National de la Santé et de la Recherche Médicale (INSERM), Infection, Antimicrobiens, Modélisation, Evolution, Unité Mixte de Recherche (UMR) 1137</institution>,<country>Paris, France</country><institution>; Université Paris Diderot, Sorbonne Paris Cité</institution>,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Beckman Research Institute, City of Hope, 1500 E Duarte Road, Duarte</wicri:regionArea><wicri:noRegion>Duarte</wicri:noRegion><wicri:noRegion>Duarte</wicri:noRegion></affiliation></author><author><name sortKey="Rockstroh, Jurgen K" sort="Rockstroh, Jurgen K" uniqKey="Rockstroh J" first="Jürgen K." last="Rockstroh">Jürgen K. Rockstroh</name><affiliation wicri:level="1"><nlm:aff id="AF0004"><institution>Department of Internal Medicine 1, Rheinische Friedrich-Wilhelms University Bonn</institution>,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0005"><institution>German Centre of Infection Research (DZIF)</institution>,<addr-line>partner site Cologne-Bonn</addr-line>,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Institut National de la Santé et de la Recherche Médicale (INSERM), Infection, Antimicrobiens, Modélisation, Evolution, Unité Mixte de Recherche (UMR) 1137</institution>,<country>Paris, France</country><institution>; Université Paris Diderot, Sorbonne Paris Cité</institution>,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Beckman Research Institute, City of Hope, 1500 E Duarte Road, Duarte</wicri:regionArea><wicri:noRegion>Duarte</wicri:noRegion><wicri:noRegion>Duarte</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0008"><institution>Service de Maladies Infectieuses et Tropicales, Hôpital Bichat Claude Bernard</institution>,<country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Beckman Research Institute, City of Hope, 1500 E Duarte Road, Duarte</wicri:regionArea><wicri:noRegion>Duarte</wicri:noRegion><wicri:noRegion>Duarte</wicri:noRegion></affiliation></author></analytic><series><title level="j">Open Forum Infectious Diseases</title><idno type="eISSN">2328-8957</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec><title>Background.</title><p>Hepatitis C virus (HCV) infection is often asymptomatic, and the date of infection is almost impossible to determine. Furthermore, spontaneous clearance (SC) may occur, but little is known about its time of occurrence.</p></sec><sec><title>Methods.</title><p>Data on human immunodeficiency virus (HIV)-HCV coinfected individuals were used to inform a stochastic simulation model of HCV viral load kinetics, alanine aminotransferase (ALT), and HCV antibodies during acute hepatitis C. The dates of diagnosis and potential SC were estimated through a Bayesian approach. Hepatitis C virus diagnosis was assumed to be based on an elevated ALT level detected during a control visit for HIV-infected individuals, which occurred every 3 months (scenario A) or every 6 months (scenario B).</p></sec><sec><title>Results.</title><p>We found that HCV diagnosis occurred after a median of 115 days and 170 days of infection in scenarios A and B, respectively. Among spontaneous clearers, SC occurred after a median time of 184 days after infection. Seven percent (scenario B) to 10% (scenario A) of SCs appeared more than 6 months after diagnosis, and 3% (both scenarios) of SCs appeared more than 1 year after diagnosis.</p></sec><sec><title>Conclusions.</title><p>Acute hepatitis C diagnosis occurs late in HIV-HCV coinfected individuals. Screening for HCV in HIV-infected individuals should be performed frequently to reduce delays. Our findings about late occurrence of SC support “wait and see” strategies for treatment initiation from an individual basis. However, early treatment initiation may reduce HCV transmission.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Blackard, Jt" uniqKey="Blackard J">JT Blackard</name></author><author><name sortKey="Shata, Mt" uniqKey="Shata M">MT Shata</name></author><author><name sortKey="Shire, Nj" uniqKey="Shire N">NJ Shire</name></author><author><name sortKey="Sherman, Ke" uniqKey="Sherman K">KE Sherman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Orland, Jr" uniqKey="Orland J">JR Orland</name></author><author><name sortKey="Wright, Tl" uniqKey="Wright T">TL Wright</name></author><author><name sortKey="Cooper, S" uniqKey="Cooper S">S Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthews, Gv" uniqKey="Matthews G">GV Matthews</name></author><author><name sortKey="Hellard, M" uniqKey="Hellard M">M Hellard</name></author><author><name sortKey="Haber, P" uniqKey="Haber P">P Haber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vogel, M" uniqKey="Vogel M">M Vogel</name></author><author><name sortKey="Deterding, K" uniqKey="Deterding K">K Deterding</name></author><author><name sortKey="Wiegand, J" uniqKey="Wiegand J">J Wiegand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westbrook, Rh" uniqKey="Westbrook R">RH Westbrook</name></author><author><name sortKey="Dusheiko, G" uniqKey="Dusheiko G">G Dusheiko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Obermeier, M" uniqKey="Obermeier M">M Obermeier</name></author><author><name sortKey="Ingiliz, P" uniqKey="Ingiliz P">P Ingiliz</name></author><author><name sortKey="Weitner, L" uniqKey="Weitner L">L Weitner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Apers, L" uniqKey="Apers L">L Apers</name></author><author><name sortKey="Koole, O" uniqKey="Koole O">O Koole</name></author><author><name sortKey="Bottieau, E" uniqKey="Bottieau E">E Bottieau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilleece, Yc" uniqKey="Gilleece Y">YC Gilleece</name></author><author><name sortKey="Browne, Re" uniqKey="Browne R">RE Browne</name></author><author><name sortKey="Asboe, D" uniqKey="Asboe D">D Asboe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schnuriger, A" uniqKey="Schnuriger A">A Schnuriger</name></author><author><name sortKey="Dominguez, S" uniqKey="Dominguez S">S Dominguez</name></author><author><name sortKey="Guiguet, M" uniqKey="Guiguet M">M Guiguet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glynn, Sa" uniqKey="Glynn S">SA Glynn</name></author><author><name sortKey="Wright, Dj" uniqKey="Wright D">DJ Wright</name></author><author><name sortKey="Kleinman, Sh" uniqKey="Kleinman S">SH Kleinman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hajarizadeh, B" uniqKey="Hajarizadeh B">B Hajarizadeh</name></author><author><name sortKey="Grebely, J" uniqKey="Grebely J">J Grebely</name></author><author><name sortKey="Dore, Gj" uniqKey="Dore G">GJ Dore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomson, Ec" uniqKey="Thomson E">EC Thomson</name></author><author><name sortKey="Fleming, Vm" uniqKey="Fleming V">VM Fleming</name></author><author><name sortKey="Main, J" uniqKey="Main J">J Main</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nubling, Cm" uniqKey="Nubling C">CM Nübling</name></author><author><name sortKey="Unger, G" uniqKey="Unger G">G Unger</name></author><author><name sortKey="Chudy, M" uniqKey="Chudy M">M Chudy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahari, H" uniqKey="Dahari H">H Dahari</name></author><author><name sortKey="Major, M" uniqKey="Major M">M Major</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ribeiro, Rm" uniqKey="Ribeiro R">RM Ribeiro</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lavillette, D" uniqKey="Lavillette D">D Lavillette</name></author><author><name sortKey="Morice, Y" uniqKey="Morice Y">Y Morice</name></author><author><name sortKey="Germanidis, G" uniqKey="Germanidis G">G Germanidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leroy, V" uniqKey="Leroy V">V Leroy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sallie, R" uniqKey="Sallie R">R Sallie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hajarizadeh, B" uniqKey="Hajarizadeh B">B Hajarizadeh</name></author><author><name sortKey="Grady, B" uniqKey="Grady B">B Grady</name></author><author><name sortKey="Page, K" uniqKey="Page K">K Page</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vanhommerig, Jw" uniqKey="Vanhommerig J">JW Vanhommerig</name></author><author><name sortKey="Thomas, Xv" uniqKey="Thomas X">XV Thomas</name></author><author><name sortKey="Van Der Meer, Jt" uniqKey="Van Der Meer J">JT van der Meer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stolte, G" uniqKey="Stolte G">G Stolte</name></author><author><name sortKey="Dukers, Nh" uniqKey="Dukers N">NH Dukers</name></author><author><name sortKey="De Wit, Jb" uniqKey="De Wit J">JB de Wit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elford, J" uniqKey="Elford J">J Elford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Helm, Jj" uniqKey="Van Der Helm J">JJ van der Helm</name></author><author><name sortKey="Prins, M" uniqKey="Prins M">M Prins</name></author><author><name sortKey="Del Amo, J" uniqKey="Del Amo J">J del Amo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaplan Lewis, E" uniqKey="Kaplan Lewis E">E Kaplan-Lewis</name></author><author><name sortKey="Fierer, Ds" uniqKey="Fierer D">DS Fierer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Morlat, P" uniqKey="Morlat P">P. Morlat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomson, Ec" uniqKey="Thomson E">EC Thomson</name></author><author><name sortKey="Nastouli, E" uniqKey="Nastouli E">E Nastouli</name></author><author><name sortKey="Main, J" uniqKey="Main J">J Main</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vispo, E" uniqKey="Vispo E">E Vispo</name></author><author><name sortKey="Barreiro, P" uniqKey="Barreiro P">P Barreiro</name></author><author><name sortKey="Plaza, Z" uniqKey="Plaza Z">Z Plaza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shores, M" uniqKey="Shores M">M Shores</name></author><author><name sortKey="Soriano, N" uniqKey="Soriano N">N Soriano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harfouch, S" uniqKey="Harfouch S">S Harfouch</name></author><author><name sortKey="Guiguet, M" uniqKey="Guiguet M">M Guiguet</name></author><author><name sortKey="Valantin, Ma" uniqKey="Valantin M">MA Valantin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lunge, Vr" uniqKey="Lunge V">VR Lunge</name></author><author><name sortKey="Da Rocha, Db" uniqKey="Da Rocha D">DB da Rocha</name></author><author><name sortKey="Beria, Ju" uniqKey="Beria J">JU Béria</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Ragonnet, Romain" sort="Ragonnet, Romain" uniqKey="Ragonnet R" first="Romain" last="Ragonnet">Romain Ragonnet</name></noRegion><name sortKey="Deuffic Burban, Sylvie" sort="Deuffic Burban, Sylvie" uniqKey="Deuffic Burban S" first="Sylvie" last="Deuffic-Burban">Sylvie Deuffic-Burban</name><name sortKey="Deuffic Burban, Sylvie" sort="Deuffic Burban, Sylvie" uniqKey="Deuffic Burban S" first="Sylvie" last="Deuffic-Burban">Sylvie Deuffic-Burban</name><name sortKey="Guedj, Jeremie" sort="Guedj, Jeremie" uniqKey="Guedj J" first="Jeremie" last="Guedj">Jeremie Guedj</name><name sortKey="Guiguet, Marguerite" sort="Guiguet, Marguerite" uniqKey="Guiguet M" first="Marguerite" last="Guiguet">Marguerite Guiguet</name><name sortKey="Lacombe, Karine" sort="Lacombe, Karine" uniqKey="Lacombe K" first="Karine" last="Lacombe">Karine Lacombe</name><name sortKey="Lacombe, Karine" sort="Lacombe, Karine" uniqKey="Lacombe K" first="Karine" last="Lacombe">Karine Lacombe</name><name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name><name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name></country><country name="Australie"><noRegion><name sortKey="Ragonnet, Romain" sort="Ragonnet, Romain" uniqKey="Ragonnet R" first="Romain" last="Ragonnet">Romain Ragonnet</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Boesecke, Christoph" sort="Boesecke, Christoph" uniqKey="Boesecke C" first="Christoph" last="Boesecke">Christoph Boesecke</name></noRegion><name sortKey="Boesecke, Christoph" sort="Boesecke, Christoph" uniqKey="Boesecke C" first="Christoph" last="Boesecke">Christoph Boesecke</name><name sortKey="Rockstroh, Jurgen K" sort="Rockstroh, Jurgen K" uniqKey="Rockstroh J" first="Jürgen K." last="Rockstroh">Jürgen K. Rockstroh</name><name sortKey="Rockstroh, Jurgen K" sort="Rockstroh, Jurgen K" uniqKey="Rockstroh J" first="Jürgen K." last="Rockstroh">Jürgen K. Rockstroh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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